#NFkB

Inflammation: The Biological Fire That Burns Chronically

Acute inflammation is the body's essential wound-healing and pathogen-defence mechanism, orchestrated through prostaglandin synthesis, cytokine signalling, complement activation, and neutrophil mobilisation in a tightly regulated cascade that resolves within days. Chronic low-grade inflammation — driven by persistent gut dysbiosis, toxic burden, glycaemic dysregulation, and omega-6:omega-3 imbalance — hijacks these same pathways into a sustained state of immune activation that is the common underlying mechanism of cardiovascular disease, type 2 diabetes, cancer, neurodegenerative conditions, and autoimmune disease. The pharmaceutical industry's answer — anti-inflammatory drugs that block these pathways without addressing their cause — treats the smoke alarm whilst ignoring the fire.