COAGULATION BIOLOGY & MICROCLOTTING

The Silent Blood Crisis Driving Strokes, Fatigue, and Long-Term Illness.

The coagulation cascade — the complex sequence of enzymatic reactions that converts soluble fibrinogen into insoluble fibrin clots — is one of the most tightly regulated biological systems in the human body. When chronically dysregulated, hypercoagulability produces microclots — tiny fibrin aggregates too small to cause acute events but large enough to obstruct capillary beds, impair tissue oxygenation, and generate the microvascular hypoxia that explains the fatigue, cognitive dysfunction, and organ stress of Long COVID, ME/CFS, and post-viral syndromes. Emerging research by Professor Resia Pretorius has demonstrated amyloid-containing microclots in the blood of Long COVID patients that resist normal fibrinolysis — a finding with profound implications for the estimated 2 million UK Long COVID sufferers. Platelet hyperactivation, elevated D-dimer, disrupted fibrinolysis, and thromboinflammation are the measurable signatures of this crisis.