URIC ACID & PURINE METABOLISM

The Metabolic Molecule Driving Disease Far Beyond Gout.

Uric acid — produced as the terminal breakdown product of purines in humans — was long viewed simply as the cause of gout. Research by Dr Richard Johnson at the University of Colorado has revealed a far more significant role: fructose-driven uric acid spikes are a primary metabolic trigger for hypertension, insulin resistance, non-alcoholic fatty liver disease, kidney disease, and cognitive decline. The fructose-uric acid pathway explains why high-fructose corn syrup, fruit juice, and even 'natural' fruit sugar at modern consumption levels drive metabolic syndrome independently of caloric intake. Uric acid above 5.5 mg/dL — below the clinical gout threshold — predicts metabolic and cardiovascular disease decades before conventional markers signal pathology. This is one of the most important and most overlooked metabolic markers in preventive medicine.