CHRONIC FATIGUE & ME/CFS

The Disease Medicine Refuses to Understand.

Myalgic Encephalomyelitis / Chronic Fatigue Syndrome affects an estimated 250,000 people in the UK and remains one of the most profoundly mismanaged conditions in the NHS, routinely dismissed as psychological despite extensive evidence of mitochondrial dysfunction, immune activation, autonomic nervous system dysregulation, and viral persistence. Post-exertional malaise — the hallmark of ME/CFS where symptoms worsen dramatically after minimal physical or cognitive effort — is now measurably linked to impaired cellular energy production and disrupted oxidative phosphorylation in mitochondria.