HISTAMINE INTOLERANCE & MAST CELL ACTIVATION

The Invisible Trigger Behind Chronic Inflammation.

Histamine intolerance — the inability to break down histamine faster than it accumulates — and Mast Cell Activation Syndrome (MCAS) represent an emerging class of conditions that explain chronic unexplained symptoms including flushing, hives, migraines, gut disorders, heart palpitations, anxiety, and chronic fatigue in millions of undiagnosed individuals. The enzyme diamine oxidase (DAO), which degrades histamine in the gut, is suppressed by gut dysbiosis, leaky gut, alcohol, NSAID use, and oestrogen excess. Mast cells — the histamine-releasing immune sentinels found in every tissue — become chronically hyper-reactive in response to ongoing environmental toxic burden.