Psychedelics &amp; Therapeutic Neuroscience

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2C-B and the Serotonin 2C Receptor: Mapping the Molecular Profile of Hybrid Entactogens

Discover how 2C-B bridges classic psychedelics and entactogens through its unique, high-affinity interaction with serotonin 2C receptors.

Scientific illustration for The Thalamic Filter Theory: Deciphering Sensory Gating in the Psychedelic State

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The Thalamic Filter Theory: Deciphering Sensory Gating in the Psychedelic State

Discover how psychedelics disrupt the brain's thalamic filter, unlocking profound neurobiological insights into sensory gating and conscious experience.

Scientific illustration for Microdosing and Mitochondrial Function: Assessing the Biological Efficacy of Sub-Perceptual Doses

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Microdosing and Mitochondrial Function: Assessing the Biological Efficacy of Sub-Perceptual Doses

Discover how microdosing psychedelics enhances mitochondrial function, driving cellular energy and cognitive vitality at a molecular level.

Scientific illustration for Mescaline Pharmacodynamics: Exploring the Biological Action of Phenethylamines on the Human Brain

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Mescaline Pharmacodynamics: Exploring the Biological Action of Phenethylamines on the Human Brain

Discover how mescaline’s unique phenethylamine structure interacts with catecholamine pathways to shape its distinct central nervous system pharmacodynamics.

Scientific illustration for The Role of the Claustrum in Psychedelic States: A Biological Perspective on Orchestrated Consciousness

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The Role of the Claustrum in Psychedelic States: A Biological Perspective on Orchestrated Consciousness

Discover how the claustrum acts as the brain's conductor of consciousness, regulating multisensory integration during profound psychedelic states.

Scientific illustration for Psilocybin and the Deactivation of the Brain's Default Mode Network

17 MIN READ

• Jun 2026

Psilocybin and the Deactivation of the Brain's Default Mode Network

Discover how psilocybin disrupts ingrained patterns of depressive thinking by temporarily resetting the brain's default mode network. Research from Imperial College London suggests this mechanism offers a lasting neurological shift that traditional antidepressants cannot replicate.

#Psilocybin#Depression

Jun 2026

Scientific illustration for Ketamine Therapy: Bridging the Gap for Treatment-Resistant Depression

• Jun 2026

Ketamine Therapy: Bridging the Gap for Treatment-Resistant Depression

While traditional antidepressants target serotonin, ketamine acts on the glutamate system to provide rapid relief for severe depression. Explore the science behind this dissociative anaesthetic and its growing availability in UK private clinics.

#Ketamine#Depression

Jun 2026

Scientific illustration for MDMA-Assisted Psychotherapy: A Paradigm Shift for Treatment-Resistant PTSD

• Jun 2026

MDMA-Assisted Psychotherapy: A Paradigm Shift for Treatment-Resistant PTSD

MDMA-assisted therapy allows trauma survivors to process painful memories without being overwhelmed by the brain's fear response. Recent trials demonstrate that 67% of participants no longer meet PTSD criteria after just three sessions, a result far exceeding current UK standard care.

#MDMA#PTSD

Jun 2026

Scientific illustration for The Gut-Brain Axis and Ayahuasca: How Traditional Brews Modulate Enteric Neuroscience

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The Gut-Brain Axis and Ayahuasca: How Traditional Brews Modulate Enteric Neuroscience

Discover how Ayahuasca modulates the enteric nervous system via the gut-brain axis, unlocking novel biological insights into this ancient brew.

Scientific illustration for Phylogenetic Perspectives: The Evolutionary Origin of Serotonergic Psychedelics in Plant and Fungal Biology

7 MIN READ

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Phylogenetic Perspectives: The Evolutionary Origin of Serotonergic Psychedelics in Plant and Fungal Biology

Discover the evolutionary origins of serotonergic psychedelics and gain a deeper innerstanding of how these powerful molecules shaped plant and fungal biology.

Scientific illustration for Neuroendocrine Effects of Psychedelics: Impact on the Hypothalamic-Pituitary-Adrenal Axis

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Neuroendocrine Effects of Psychedelics: Impact on the Hypothalamic-Pituitary-Adrenal Axis

Explore how psychedelics modulate the HPA axis to recalibrate the body's stress response and drive profound psychological healing.

Scientific illustration for The Pharmacokinetics of Psilocin: Examining Bioavailability and Metabolism in the Human Body

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The Pharmacokinetics of Psilocin: Examining Bioavailability and Metabolism in the Human Body

Discover how psilocybin metabolises into active psilocin, revealing the biological mechanisms and pharmacokinetics that drive therapeutic neuroscience.

Scientific illustration for LSD and Cortical Integration: Examining the Biology of Enhanced Global Connectivity

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• May 2026

LSD and Cortical Integration: Examining the Biology of Enhanced Global Connectivity

An investigation into the neurobiology of LSD, detailing how 5-HT2A receptor activation diminishes modular boundaries to foster heightened global integration across cortical networks.

May 2026

Scientific illustration for Ibogaine’s Impact on Neurogenesis: A Molecular Investigation into Opioid Receptor Modulation

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• May 2026

Ibogaine’s Impact on Neurogenesis: A Molecular Investigation into Opioid Receptor Modulation

An analysis of ibogaine’s molecular impact on neurogenesis, detailing the signaling pathways through which opioid receptor modulation stimulates structural brain remodeling and repair.

May 2026

Scientific illustration for DMT and the Sigma-1 Receptor: Understanding the Intracellular Mechanism of the Spirit Molecule

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• May 2026

DMT and the Sigma-1 Receptor: Understanding the Intracellular Mechanism of the Spirit Molecule

Explore DMT as an endogenous Sigma-1 receptor ligand. This technical overview examines the intracellular pathways and chaperone functions driving neuroplasticity and cellular resilience.

May 2026

Scientific illustration for Salvinorin A and the Kappa Opioid Receptor: A Non-Serotonergic Pathway to Altered Consciousness

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Salvinorin A and the Kappa Opioid Receptor: A Non-Serotonergic Pathway to Altered Consciousness

Discover how Salvinorin A uniquely bypasses serotonin, acting as a powerful kappa-opioid receptor agonist to induce profound altered states of consciousness.

Scientific illustration for 5-MeO-DMT and Neuroinflammation: Investigating the Immunomodulatory Potential of the Toad Secretion

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5-MeO-DMT and Neuroinflammation: Investigating the Immunomodulatory Potential of the Toad Secretion

Discover how 5-MeO-DMT from the Sonoran Desert toad modulates the immune system and reduces neuroinflammation, unlocking new neurological therapies.

Scientific illustration for Neuroplasticity: How Psychedelics Re-Wire Neural Connections

17 MIN READ

Neuroplasticity: How Psychedelics Re-Wire Neural Connections

Psychedelics are 'psychoplastogens' that promote the growth of new dendritic spines and strengthen synaptic connections. Learn how this 'plastic window' provides a unique opportunity for long-term mental health recovery and habit change.

#Neuroplasticity#BDNF