NAD+: The Molecule of Life and Longevity
Nicotinamide adenine dinucleotide (NAD+) is a coenzyme present in every cell of the body that serves as the essential electron carrier in the mitochondrial electron transport chain, the substrate for SIRT1 through SIRT7 longevity-associated sirtuins, the fuel for PARP DNA repair enzymes, and a critical regulator of the circadian clock — making it arguably the most important molecule in the biology of ageing, energy production, and disease prevention. NAD+ levels decline precipitously with age, chronic alcohol consumption, inflammatory conditions, and genotoxic exposure, creating a cellular energy and repair deficit that underlies the pathology of neurodegeneration, cancer, metabolic disease, and immunological collapse. The urgent conversation about NAD+ precursors and restoration strategies is one of the most significant developments in functional medicine.
